Government & NGOs
[LESS INFO] 312 VIEWS | ADDED 20:16:57 06/09/10
Daniel Silver, MD, PhD
[LESS INFO] 160 VIEWS | ADDED 10:29:59 04/26/10
With Dr. Robert DeRubeis, University of Pennsylvania.
[LESS INFO] 77 VIEWS | ADDED 10:29:59 04/26/10
With Dr. Robert DeRubeis, University of Pennsylvania.
[LESS INFO] 50 VIEWS | ADDED 11:50:36 10/06/09
Dr. Stephen T. Warren Emory University School of Medicine Please join the Congressional Biomedical Research Caucus in welcoming Dr. Stephen Warren. Dr. Warren led the research that discovered how the gene mutation responsible for Fragile X Syndrome (FXS) alters the way brain cells communicate. FXS is the most commonly inherited form of mental retardation, with nearly a third of FXS patients also having autism, making FXS the single best understood cause of autism and a model for autism research. FXS is caused by a mutation in the FMR1 gene on the X chromosome. Dr. Warren and his colleagues led an international team that discovered the FMR1 gene in 1991.They found that in patients with FXS, the expanded CGG triplet repeats can be repeated from 55 to over 200 times, whereas in healthy individuals the repeats range from 40 to fewer than 10. As a result of the hyper-CGG repeats, the expression of the FMR1 gene is repressed, which leads to the absence of FMR1 protein and subsequent mental retardation. Dr. Warren and his team have since developed diagnostic tests for FXS. Clinical trials are now under way for FXS, taking advantage of the fundamental basic science research on FXS carried out over the past two decades. FXS is now used as a model of how fundamental research on autism could lead the way for future therapeutic interventions in autistic disorders.
[LESS INFO] 95 VIEWS | ADDED 06:48:29 09/22/09
Please join Dr. Carson and the CBRC who will ask us to look at the deterioration of memory in older adults in a new light — not that of a mind being ravaged by dementia, but instead a mind widening its ability to process more details than that of a younger brain. For decades, cognitive research on the older brain has focused on the decline of thinking abilities. Newer research, however, suggests that much of this observed decline may actually result from lifestyle changes or illness rather than from inevitable brain atrophy. Dr. Carson will highlight how scientists are now beginning to focus on ways that cognition can actually improve with age. Research suggests that brainpower is not declining but that more information is being processed. Dr. Carson will review the research on age-related brain changes and brain plasticity, and discuss how these changes affect wisdom and creativity. She will also discuss initiatives to maintain and even improve cognition in later years. The Congressional Biomedical Research Caucus provides a forum where Members and staff can interact directly with preeminent researchers responsible for important scientific discoveries. Many of the stunning advances, made possible by NIH funding, highlighted in these presentations have led to improved understanding of the cause, treatment, and prevention of human disease.
[LESS INFO] 26 VIEWS | ADDED 12:46:24 07/30/09
Dr. Keith Yamamoto University of California, San Francisco Wednesday, July 22, 2009 Please join the Congressional Biomedical Research Caucus in welcoming Dr. Keith Yamamoto of the University of California, San Francisco (USCF). Each year Congress appropriates billions of dollars to fund the National Institutes of Health (NIH). Did you ever consider how the money is distributed? With a budget of roughly $30 billion per year, the decisions that most strongly influence allocation of NIH funds are made by peer review by groups of professional scientists who typically are themselves funded by NIH. Is peer review really the best way to fund biomedical research? Are there intrinsic problems that compromise it? Could changes in peer review improve the quality of research? These and other issues will be discussed by Dr. Keith R. Yamamoto, an active scientist who has been involved in NIH peer review for almost 25 years, most recently leading an overall evaluation that produced key changes in the process.
Innovation through Education: Harnessing the Energy of Young Scientists in the International Genetically Engineered Machine Competition
[LESS INFO] 31 VIEWS | ADDED 07:28:25 07/21/09
Dr. Wendell Lim, of the University of California, San Francisco (USCF) Department of Cellular and Molecular Pharmacology, shares his experience with the International Genetically Engineered Machine (iGEM) Competition, a “Biotechnology Olympics” that brings together teams of students whose challenge is to design and build a novel genetically engineered system that carries out a useful function. The projects that have emerged from iGEM rival those of professional research laboratories and biotechnology companies in sophistication, and frequently exceed them in innovative thinking. Dr. Lim discusses how this innovative contest foreshadows new ways in which biology could be taught, practiced, and applied in the future.
[LESS INFO] 12 VIEWS | ADDED 04:13:38 06/18/09
Dr. Boult has long been interested in developing and testing novel approaches to organizing, financing, and delivering health care to older populations, as well as improving the outcomes experienced by people whose chronic illnesses require care that spans the hospital, post-acute, and home care settings. His briefing will focus on the concept of Guided Care, a new model of comprehensive health care that constitutes a type of "medical home" for high-cost Medicare beneficiaries. In the first year of a recent federally funded, multi-site, randomized controlled trial at Johns Hopkins, Guided Care significantly increased the quality of health care for this population while reducing the total cost of its care by 11% ($1,365 per beneficiary per year).
[LESS INFO] 57 VIEWS | ADDED 13:50:25 06/15/09
Dr. William Wulf University of Virginia There is an ecology of interacting laws, regulations and institutions that are intended to support innovation – a traditional strength of the U.S. Unfortunately, the current elements of that ecology were designed a long time ago for the technologies that existed at that time and are not well suited to the technologies of today and tomorrow. This talk explores the nature of the problem and some possible solutions.
[LESS INFO] 41 VIEWS | ADDED 10:23:32 06/05/09
Dr. Atul Butte of Stanford University is at the forefront of the nascent field of translational bioinformatics—a field that seeks to create new diagnostics and therapeutics from genome-era information and data. At a Congressional Biomedical Caucus Briefing on June 3, 2009, he highlighted how new uses for publicly available data have enabled us to ask new questions, including rethinking the nature of disease.
[LESS INFO] 21 VIEWS | ADDED 09:21:30 05/26/09
Dr. Martin Chalfie's discussion Molecules to Spy on Cells highlighted his ground-breaking research on green flourescent protein (GFP). He and colleagues revolutionized how scientists study the mechanics of cells by getting a visual fix on how organs function. GFP is a small, inert, and relatively nontoxic molecule, easily diffused through living tissue. Researchers now have the ability to follow various cells with the help of GFP. They can study nerve cell damage during Alzheimer's disease, how insulin-producing beta cells are created in the pancreas of a growing embryo, or how cancer cells spread. In one spectacular experiment, researchers succeeded in tagging different nerve cells with a kaleidoscope of colors in the brain of a mouse. Dr. Chalfie is the William R. Kenan, Jr., Professor of Biological Sciences at Columbia University, where he is also chair of the Department of Biological Sciences. He shared the 2008 Nobel Prize in Chemistry with Osamu Shimomura and Roger Y. Tsien for the discovery and development of the green fluorescent protein, GFP.
[LESS INFO] 24 VIEWS | ADDED 13:39:14 05/15/09
Dr. Leslie Vosshall from Rockefeller University
[LESS INFO] 6 VIEWS | ADDED 14:56:09 04/28/09
World-renowned virus hunter Nathan Wolfe discusses his plan to outwit the next pandemic. Dr. Wolfe’s plan is to stay two steps ahead of the next pandemic by discovering new, deadly viruses when they first emerge — passing from animals to humans among poor subsistence hunters in central Africa — and stopping them before they infect millions of people.
[LESS INFO] 130 VIEWS | ADDED 15:17:31 03/27/09
Dr. David Botstein The Lewis-Sigler Institute at Princeton University Join world-renowned geneticist and pioneer of the Human Genome Project, David Botstein, as he discusses how the mapping of the human genome has transformed medicine. The Human Genome Project, completed in April 2003, mapped the location of each of the genes in the human genome and decoded, or sequenced, each gene's instruction. Because of the complexity of our genomes, the ability to obtain genomic sequences depends on revolutionary advances in speed, capacity, and versatility of digital computers. Using a combination of new DNA chemistry and computational methods, scientists have identified thousands of genes that cause inherited diseases. Among them are genes that cause inherited predispositions to breast cancer, colon cancer, and kidney cancer, among others. With these methods it has become possible to study, at a comprehensive level, the differences in gene activity that accompany the transformation of tissues from normal to cancerous, and to classify different subtypes of cancers by their “molecular signatures.” We now can distinguish several kinds of breast cancer, some of which are more aggressive and lethal than others, and some of which are uniquely sensitive to new classes of targeted drugs.
[LESS INFO] 49 VIEWS | ADDED 07:13:09 03/18/09
Dr. Susan B. Roberts of Tufts University, says that to change obesity, we must focus on food. There has been an average increase of 564 calories in the U.S. food supply since 1975, primarily caused by high fructose corn syrup and oil. Additionally, the explosion in U.S. food supply variety since 1980 coincides with increasing weight gain. The four most effective ways to control hunger are high fiber, high protein, low glycemic index, and high volume (low energy density). People should have realistic expectations for weight loss and eat foods that satisfy basic hardwired biology. Society needs to address the issue from all sides, including consumers, the media, scientists and government.
[LESS INFO] 387 VIEWS | ADDED 06:09:40 03/18/09
Join Dr. Stephen Young as he discusses how his laboratory is testing new methods using a drug targeted for cancer — the farnesyltransferase inhibitor—that has been shown to reduce the severity of the disease. Children with HGPS have cells with deformed nuclei. Tests on mice show that treatment with the drug results in a higher proportion of normally shaped nuclei, which leads to a decrease in the severity of symptoms and an increase in bone density. Based on these findings, this drug is now being tested in children with HGPS.